pentobarbital improves amounts of vortioxetine by increasing metabolism. Modify Therapy/Observe Intently. Consider growing the vortioxetine dose when coadministered with strong CYP inducers for >14 days; never to exceed 3 times primary vortioxetine dose.pentobarbital will minimize the level or result of ombitasvir/paritaprevir/ritonavir & dasabuvir